Cardiac Surgery, Cardiac Anesthesia

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صفحه اصلیمقالاتPublished Article on:Effect of 1, 25 (OH)2 Vitamin D3 on Serum Levels of Inflammatory Cytokines in Patients Undergoing Coronary Artery Bypass Grafting
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Published Article on:Effect of 1, 25 (OH)2 Vitamin D3 on Serum Levels of Inflammatory Cytokines in Patients Undergoing Coronary Artery Bypass Grafting

Effect of 1, 25 (OH)2 Vitamin D3 on Serum Levels of Inflammatory Cytokines in Patients Undergoing Coronary Artery Bypass Grafting

Background: A number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none has been considered definitive. 1,25 (OH)2 vitamin D3 is a type of physiologic hormones with immunomodulatory effects. This study assessed the effect of oral vitamin D on serum levels of interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha (TNF-α) in adult coronary artery bypass grafting (CABG).

Materials and methods: In a double blind placebo controlled clinical trial, with a sample size of 80 patients, randomly assigned in either the placebo group (including 40 patients; placebo pills) or the intervention group (i.e. 40 patients; vitamin D pearls), CABG surgery with cardiopulmonary bypass was performed. Serum cytokines (IL-1, IL-6, and TNF-α) were evaluated preoperatively and during the first postoperative day.

Results: Serum TNF-α level was similar in the two groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in vitamin D group.

Conclusion: The current study demonstrated that oral vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).

Keywords: Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation

Kamal Fani , Mahdi Shadnoush , Alireza Jahangirifard, Mahnoosh Foroughi, Hosein Ali JelvehMoghaddam, Ali Dabbagh

 

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