Cardiac Surgery, Cardiac Anesthesia


صفحه اصلیمقالاتBasic Clinical Pharmacology Toxicology

Basic Clinical Pharmacology Toxicology

Effect of Desmopressin on the Amount of Bleeding and Transfusion Requirements in

Patients Undergoing Heart Transplant Surgery

Alireza Jahangirifard, Mohammad Reza Razavi, Zargham Hosein Ahmadi and Mohammad Forozeshfard

Cardiac Anesthesiology, Tracheal Diseases Research Center, NRITLD, Shaheed Beheshti University of Medical Sciences, Tehran, Iran, Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran, Department of Surgery, Masih Daneshvari Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran and Cancer Research Center and Department of Anesthesiology, Semnan University of Medical Sciences, Semnan, Iran

(Received 1 December 2016; Accepted 15 March 2017)

Abstract: One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surgery were randomly assigned to two groups. In the intervention group, patients received desmopressin of 0.3 lg/kg, 30 min. before surgery. Patients in the control group received normal saline at the same amount and time. Homeostasis was evaluated using activated clotting time (ACT), PT, PTT and PLT before, 12 and 24 hr after surgery, and also, chest tube drainage, blood products transfusion requirements during the first day in both groups. No significant differences were found between the groups in terms of ACT, PT, PTT and PLT at all times. Transfusion of packed red blood cells and the mean drainages of chest tube during the first 24 hr after surgery were significantly lower in the desmopressin group compared to the saline group. Desmopressin may reduce post-operative bleeding in patients undergoing heart transplant surgery. Further studies are required to confirm the potential effect of desmopressin on establishing haemostasis after heart transplantation

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